Issue, March, 2025
Newsletter
Conceptual Medicine
Conceptual Medicine: Master Medicine with Expert-Led Learning
Welcome to the very first edition of Conceptual Medicine’s Newsletter! We bring you a curated selection of high-impact videos, offering in-depth insights into key medical topics. This is just a glimpse—our platform has so much more to explore!
Here are the five most-viewed videos this month, handpicked for Medicine residents like you:
1. Most Sensitive Test for Detecting Recurrent Cushing’s Disease By Dr. Dilip Kumar
Cushing’s disease presents unique diagnostic challenges, especially in cases of recurrence. How do you accurately diagnose it? In this session, Dr. Dilip Kumar explains why Late Night Salivary Cortisol (LNSC) is the most sensitive test and how it compares with other diagnostic methods.
What You’ll Learn:
- Why LNSC is the most sensitive test for recurrence detection
- The role of 24-hour urinary free cortisol and dexamethasone suppression test in diagnosis
- Why biochemical testing precedes imaging in Cushing’s workup
- When to use Inferior Petrosal Sinus Sampling (IPSS) for pituitary adenoma recurrence
This video is a must-watch for residents dealing with endocrine disorders. Learn the gold-standard approach to diagnosing Cushing’s recurrence and refine your clinical skills.
2. A Simplified Guide to Medicine: Pathogenesis of SLE by Dr. Suvrat Arya
Systemic Lupus Erythematosus (SLE) is one of the most complex autoimmune diseases, but understanding its pathogenesis is crucial for both exams and clinical practice. Dr. Suvrat Arya simplifies this topic using a visual approach, making it easy to grasp key mechanisms.
What You’ll Learn:
- Genetic Predisposition – HLA associations (HLA-DRB1, DR3, DQA2), TREX1 mutations, complement deficiencies (C1q, C2, C4)
- Immune Dysfunction – Role of B cells, T cells, and genes like BANK1, STAT4 in autoantibody production
- Environmental Triggers – UV exposure, smoking, viral infections (EBV, CMV)
- Epigenetic Changes – How DNA methylation and histone modifications drive SLE progression
- Clinical Manifestations – Fever, rash, joint pain, nephritis, severe organ involvement
- Diagnosis & Treatment – ANA, dsDNA, complement levels, and immunosuppressive therapy
If you struggle with SLE pathogenesis, this video provides the clarity you need!
3. Understanding the Pathogenesis of Hepatitis A & E By Dr. Umalakshmi Premnath
Hepatitis A and E are often misunderstood as simple viral infections, but they have complex pathophysiology that primarily involves immune-mediated liver injury. Dr. Umalakshmi Premnath breaks it down with clarity, helping you master this crucial topic.
What You’ll Learn:
- Immune vs. Cytopathic Damage – Understanding why these viruses don’t directly damage liver cells
- Role of the Immune System – NK cells, interferons, interleukins, and T cells in causing hepatocyte injury
- Virus Shedding & Transmission – How HEV spreads before symptoms appear
- Diagnostic Approach – IgM vs. IgG testing, liver biopsy findings
- Atypical Manifestations – Prolonged hepatitis, relapsing phase, cholestasis
- Vaccination – Monovalent vs. divalent vaccines and their effectiveness
This is an essential video for understanding the pathogenesis and clinical implications of Hepatitis A & E.
4. Kidney Failure Risk Equation (KFRE) Explained – Dr. A. S. Nath
How do we predict which CKD patients will progress to kidney failure? The Kidney Failure Risk Equation (KFRE) is a validated tool that helps clinicians determine who needs early intervention and nephrology referral.
What You’ll Learn:
- What is KFRE? – A risk prediction model developed in Canada, validated on 700,000+ patients
- Essential Predictors – GFR, proteinuria, serum albumin, phosphorus, bicarbonate levels
- Clinical Utility – Who needs early nephrology referral? When to prepare for dialysis?
- Real Patient Case Discussions – Learn how KFRE is applied in actual clinical settings
This video is a must-watch for any Medicine resident handling CKD patients.
5. Clinically Relevant Fungi & Their Impact – Dr. Dilip Kumar
Fungal infections are becoming increasingly common, especially in ICU patients and immunocompromised individuals. Do you know how to identify and manage them effectively? Dr. Dilip Kumar provides a deep dive into clinically significant fungi and their diagnosis.
What You’ll Learn:
- Candida – Bloodstream infections, ICU-related risks, and morphology
- Cryptococcus – Meningitis in immunosuppressed patients, India ink staining
- Trichosporon – Bloodstream infections, barrel-shaped arthroconidia
- Geotrichum – Pulmonary infections, morphology
- Rare Fungi – Prototheca, Saccharomyces, and emerging infections
- Diagnostic Tools – KOH mount, GMS stain, culture methods
Mastering fungal infections is crucial for ICU management and infectious disease rotations.
Expand Your Knowledge with Conceptual Medicine!
This is just a preview of what Conceptual Medicine offers. Our platform is packed with high-yield, expert-led content to help you: Master medical concepts effortlessly, prepare for residency, clinical practice, and competitive exams, Stay updated with the latest guidelines & diagnostic techniques
👉 Start Learning Today
Stay tuned for our next edition, where we bring more expert insights to help you excel in Medicine!
